2021 INPreps Top25 Team Power Rankings | All Classes | ( ) indicates a previous ranking
| Team | Ranking | Prev. Ranking | W-L Record | |
| Center Grove | 1 | 1 | 5-0 | |
| Cathedral | 2 | 2 | 5-0 | |
| Roncalli | 3 | 3 | 5-0 | |
| Westfield | 4 | 4 | 4-1 | |
| Merrillville | 5 | 5 | 5-0 | |
| Valparaiso | 6 | 7 | 5– | |
| Brebeuf Jesuit | 7 | 8 | 5-0 | |
| Carmel | 8 | 9 | 4-1 | |
| Brownsburg | 9 | 10 | 4-1 | |
| Bishop Luers | 10 | 12 | 5-0 | |
| Warren Central | 11 | 19 | 4-1 | |
| West Lafayette | 12 | 16 | 5-0 | |
| Bloomington South | 13 | NR | 5-0 | |
| Gibson Southern | 14 | 14 | 4-1 | |
| Hamilton SE | 15 | 17 | 4-1 | |
| Leo | 16 | NR | 5-0 | |
| Chesterton | 17 | 20 | 4-1 | |
| Decatur Central | 18 | NR | 4-1 | |
| East Central | 19 | 22 | 4-1 | |
| Mooresville | 20 | 13 | 4-1 | |
| Andrean | 21 | 24 | 3-2 | |
| Lawrence North | 22 | 11 | 4-1 | |
| Danville | 23 | 25 | 4-1 | |
| Carroll | 24 | NR | 4-1 | |
| Indy Lutheran | 25 | NR | 5-0 | |
| In Consideration: East Noble, Mishawaka, Jasper, Eastbrook, Lawrenceburg | ||||
| Dropped Out: | ||||
| Homestead | 18 | 23 | 3-2 | |
| FW Dwenger | 19 | 6 | 3-2 | |
| Fishers | 21 | 21 | 3-2 | |
| Ben Davis | 23 | 15 | 2-3 |
