2021 Indiana Preps Top 25 Team Power Rankings | All Classes | ( ) indicates the previous ranking
| Team | Ranking | Prev. Ranking | W-L Record |
| Center Grove | 1 | 0-0 | |
| Cathedral | 2 | 0-0 | |
| Roncalli | 3 | 0-0 | |
| Westfield | 4 | 0-0 | |
| Zionsville | 5 | 0-0 | |
| Carmel | 6 | 0-0 | |
| Ben Davis | 7 | 0-0 | |
| Warren Central | 8 | 0-0 | |
| Chatard | 9 | 0-0 | |
| Merrillville | 10 | 0-0 | |
| Brownsburg | 11 | 0-0 | |
| Elkhart | 12 | 0-0 | |
| Lafayette Jeff | 13 | 0-0 | |
| FW Dwenger | 14 | 0-0 | |
| Danville | 15 | 0-0 | |
| Homestead | 16 | 0-0 | |
| Valparaiso | 17 | 0-0 | |
| Andrean | 18 | 0-0 | |
| Lawrenceburg | 19 | 0-0 | |
| Avon | 20 | 0-0 | |
| Penn | 21 | 0-0 | |
| Whiteland | 22 | 0-0 | |
| Bishop Luers | 23 | 0-0 | |
| New Palestine | 24 | 0-0 | |
| Lawrence North | 25 | 0-0 |