2021 INPreps Top25 Team Power Rankings | All Classes | ( ) indicates a previous rankin
| Team | Ranking | Prev. Ranking | W-L Record | ||
| Center Grove | 1 | 1 | 8-0 | ||
| Cathedral | 2 | 2 | 8-0 | ||
| Roncalli | 3 | 3 | 8-0 | ||
| Westfield | 4 | 4 | 7-1 | ||
| Merrillville | 5 | 5 | 8-0 | ||
| Carmel | 6 | 6 | 7-1 | ||
| Bishop Luers | 7 | 7 | 8-0 | ||
| Hamilton SE | 8 | 8 | 7-1 | ||
| West Lafayette | 9 | 9 | 8-0 | ||
| Brebeuf Jesuit | 10 | 10 | 7-1 | ||
| Leo | 11 | 11 | 8-0 | ||
| Decatur Central | 12 | 12 | 7-1 | ||
| Gibson Southern | 14 | 14 | 7-1 | ||
| Brownsburg | 15 | 15 | 6-2 | ||
| Valparaiso | 16 | 16 | 7-1 | ||
| East Central | 19 | 19 | 7-1 | ||
| Andrean | 20 | 20 | 6-2 | ||
| Carroll | 21 | 21 | 7-1 | ||
| Indy Lutheran | 22 | 22 | 8-0 | ||
| Danville | 23 | 23 | 7-1 | ||
| Jasper | 24 | 24 | 8-0 | ||
| Bloomington South | 25 | 25 | 6-1 | ||
| Lawrence North | 13 | 13 | 6-2 | ||
| Chesterton | 17 | 17 | 6-2 | ||
| Warren Central | 18 | 18 | 5-3 | ||
| In Consideration: | |||||
| Heritage Christian, Eastbrook, Lawrenceburg, Mt. Vernon, Evansville Memorial, Columbus North | |||||
| Dropped Out: | |||||
| NONE |
