2021 Indiana Preps Top25 Team Power Rankings | All Classes | ( ) indicates a previous ranking
| Team | Ranking | Prev. Ranking | W-L Record | |
| Center Grove | 1 | 1 | 6-0 | |
| Cathedral | 2 | 2 | 6-0 | |
| Roncalli | 3 | 3 | 6-0 | |
| Westfield | 4 | 4 | 5-1 | |
| Merrillville | 5 | 5 | 6-0 | |
| Valparaiso | 6 | 6 | 6-0 | |
| Carmel | 7 | 8 | 5-1 | |
| Bishop Luers | 8 | 10 | 6-0 | |
| Brebeuf Jesuit | 9 | 7 | 5-1 | |
| Warren Central | 10 | 11 | 5-1 | |
| Brownsburg | 11 | 9 | 4-2 | |
| West Lafayette | 12 | 12 | 6-0 | |
| Bloomington South | 13 | 13 | 6-0 | |
| Gibson Southern | 14 | 14 | 5-1 | |
| Hamilton SE | 15 | 15 | 5-1 | |
| Leo | 16 | 16 | 6-0 | |
| Chesterton | 17 | 17 | 5-1 | |
| Decatur Central | 18 | 18 | 5-1 | |
| East Central | 19 | 19 | 5-1 | |
| Mooresville | 20 | 20 | 5-1 | |
| Andrean | 21 | 21 | 4-2 | |
| Lawrence North | 22 | 22 | 5-1 | |
| Danville | 23 | 23 | 5-1 | |
| Carroll | 24 | 24 | 5-1 | |
| Indy Lutheran | 25 | 25 | 6-0 | |
| In Consideration: Franklin Central, Jasper, Eastbrook, Lawrenceburg, Logansport | ||||
| Dropped Out: | ||||
| NONE |
