| LARGE SCHOOL | |||
| QB | Nicholas Patterson | Mooresville | |
| RB | Trey Gibson | Hobart | |
| RB | Drew Wheat | Center Grove | |
| TE | George Burhenn | Mt. Vernon Fortville | |
| WR | Jaron Tibbs | Cathedral | |
| WR | Joe Walker | Warren Central | |
| WR | TJ McWilliams | North Central | |
| OL | Trevor Lauck | Roncalli | |
| OL | Luke Burgess | New Palestine | |
| OL | Ben Decker | Noblesville | |
| OL | Ethan Trent | Carmel | |
| OL | Drew Weinzapfel | Evansville Reitz Memorial | |
| APB | Justin Marshall | Merrillville | |
| ALT | Nolan Buckman | Brebeuf Jesuit | |
| DL | Joshua Mickens | Lawrence Central | |
| DL | Kendrick Gilbert | Cathedral | |
| DL | Leighton Jones | Brownsburg | |
| DL | Brad Allen | Greenfield Central | |
| LB | Will Heldt | Carmel | |
| LB | Aycen Stevens | Decatur Central | |
| LB | Tayvion Ortman | New Prairie | |
| DB | Winston Berglund | Carmel | |
| DB | Dillon Thieneman | Westfield | |
| DB | CJ Davis | Northrop | |
| DB | Tony Leadford Jr | Pike | |
| ATH | Isaiah Thacker | New Palestine | |
| K/P | Nolan Foley | Center Grove |
Indiana Preps 2022 Preseason All State Top 22 – Big School
