2021 Indiana Preps Top 25 Team Power Rankings | All Classes | ( ) indicates the previous ranking
| Team | Ranking | Prev. Ranking | W-L Record | |
| Center Grove | 1 | 1 | 2-0 | |
| Carmel | 2 | 4 | 2-0 | |
| Cathedral | 3 | 2 | 2-0 | |
| Roncalli | 4 | 3 | 2-0 | |
| Zionsville | 5 | 5 | 2-0 | |
| Merrillville | 6 | 10 | 2-0 | |
| FW Dwenger | 7 | 8 | 2-0 | |
| Valparaiso | 8 | 11 | 2-0 | |
| Brebeuf Jesuit | 9 | 18 | 2-0 | |
| Westfield | 10 | 10 | 1-1 | |
| Brownsburg | 11 | 11 | 1-1 | |
| Homestead | 12 | 13 | 2-0 | |
| Whiteland | 13 | 14 | 1-0 | |
| Lawrence North | 14 | 15 | 1-0 | |
| Bishop Luers | 15 | 16 | 2-0 | |
| Mooresville | 16 | 21 | 2-0 | |
| Ben Davis | 17 | 17 | 1-1 | |
| West Lafayette | 18 | 19 | 2-0 | |
| Warren Central | 19 | 20 | 1-1 | |
| Gibson Southern | 20 | NR | 2-0 | |
| East Central | 21 | 24 | 2-0 | |
| Hamilton SE | 22 | NR | 2-0 | |
| Andrean | 23 | 25 | 1-1 | |
| Chesterton | 24 | NR | 2-0 | |
| Danville | 25 | 12 | 1-1 | |
| In Consideration: Fishers, Bloomington, South, Leo, East Noble ,Mishawaka, Noblesville | ||||
| Dropped Out: | ||||
| Chatard | 23 | 23 | 0-2 | |
| Decatur Central | 22 | 1-1 | ||
| Elkhart | 9 | 12 | 1-1 |
