Indiana Preps 2021 All State Top 22 – Big School (4A 5A 6A)
*Class of 2022 Seniors – Voted on by Media | Not Recruiting Based*
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| TOP 22 – BIG SCHOOL | ||
| OL | Joey Tanona | Zionsville |
| OL | Keylen Davis | Ben Davis |
| OL | Landen Livingston | Leo |
| OL | Hunter Whitenack | New Prairie |
| OL | Cooper Koers | Cathedral |
| RB | Micah Hauser | Westfield |
| RB | Lavarion Logan | Merrillville |
| TE | Jeffery Simmons | Fishers |
| WR | Omar Cooper | Lawrence North |
| WR | Chrishon McCray | Avon |
| QB | Tayven Jackson | Center Grove |
| APB | Javon Tracy | Decatur Central |
| DL | Caden Curry | Center Grove |
| DL | Dejaun Echols | Warren Central |
| DL | Kenneth Grant | Merrillville |
| DL | Popeye Williams | Westfield |
| LB | Domanick Moon | Snider |
| LB | Romero Warren Jr. | Lawrence North |
| LB | Jeff Utzinger | Cathedral |
| DB | Joseph Jefferson | Pike |
| DB | Rashon Myles Jr. | Brownsburg |
| DB | Bryce Llewellen | Cathedral |
| DB | Jahmad Harmon | Lawrence Central |
| ATH | Rowan Zolman | East Noble |
| P/K | Ben Gomez | Cathedral |